RNA and DNA interactions with proteins play a primary role in
intracellular processes. Investigating the relationships between these
macromolecules is essential for understanding mechanisms of living
organisms, disorders diagnoses, aptamer drug design, and other
applications. This study proposes an online and user-friendly network
provider tool for interactions between Nucleic Acids (NA) and
proteins. The processed and produced dataset consists of almost all
interacting macromolecules in the RCSB Protein Data Bank (PDB).
Researchers can use this online tool to focus on a preferred portion
of PDB and related relationships, visualize, and extract information.
This tool provides the frequency of atoms and residues between
proteins and NAs, and the similarity of the macromolecules` primary
structures. Also, the functional similarity of proteins can be
employed using protein families and clans from Pfam.
All files are available for download.
- Sequences (RNA, DNA, and protein) involved in complexes
- Protein Families
- Protein Clans
- Interactions
- General information
- Similarities
- Graph (pickle file of Networkx)
Predicting Affinity and Interaction based on computational approaches.